Zheng, MZM & Wakim, LM Airway tissue-resident memory T cells. Mucosal immunol. 15379-388 (2022).
Yuan, R. et al. The roles of tissue-resident memory T cells in lung disease. In front. Immunol. 12710375 (2021).
Tang, J. & Sun, J. Memory T cells residing in lung tissue: the gatekeeper of respiratory viral (re)infection. Curr. Notice. Immunol. 80102278 (2023).
Lam, N. et al. Asynchronous aging and turnover of circulating and tissue-resident human memory T cells across sites. Immunity 582271-2288.e2276 (2025).
Wu, T. et al. Memory CD8 T cells residing in the lungs (TRM) are essential for optimal cross-protection against viral pulmonary infections. J. Leukoc. Biol. 95215-224 (2014).
Slütter, B. et al. Influenza-induced lung-resident memory T cell dynamics underlie the decline in heterosubtypic immunity. Sci. Immunol. 2eaag2031 (2017).
Masopust, D. & Soerens, AG Tissue-resident T cells and other resident leukocytes. Ann. Reverend Immunol. 37521-546 (2019).
Poon, MML et al. SARS-CoV-2 infection generates tissue-localized immunological memory in humans. Sci. Immunol. 6eabl9105 (2021).
Carbone, FR Unique properties of lung tissue-resident memory T cells: implications for COVID-19 and other respiratory diseases. Nat. Reverend Immunol. 23329-335 (2023).
Szabo, PA, Miron, M. & Farber, DL Location, location, location: tissue-resident memory T cells in mice and humans. Sci. Immunol. 4eaas9673 (2019).
Yang, AY et al. Memory T cells residing in lung tissue optimize protection through regulation of innate immunity by IL-10. J.Exp. Med. 223e20242307 (2025).
Stolley, JM et al. Retrograde migration provides resident memory T cells to the lung-draining LN after influenza infection. J.Exp. Med. 217e20192197 (2020).
Rydyznski Moderbacher, C. et al. Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Cell 183996-1012.e1019 (2020).
Weiskopf, D. et al. Phenotype and kinetics of SARS-CoV-2 specific T cells in COVID-19 patients with acute respiratory distress syndrome. Sci. Immunol. 5eabd2071 (2020).
Tarke, A. et al. Vaccination against SARS-CoV-2 induces immunological memory in T cells capable of recognizing variants from Alpha to Omicron. Cell 185847-859.e811 (2022).
Sette, A., Sidney, J. and Crotty, T cell responses to SARS-CoV-2. Ann. Reverend Immunol. 41343-373 (2023).
Grifoni, A. et al. Targets of T cell responses to the SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell 1811489-1501.e1415 (2020).
Swadling, L., Fumagalli, V., Maini, MK and Iannacone, M. Abortive infection: early T cells, antibody-independent defenders. Nat. Reverend Immunol. 26327-329 (2026).
Clevers, H. Modeling development and disease with organoids. Cell 1651586-1597 (2016).
Salahudeen, AA et al. Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature 588670-675 (2020).
Tiwari, S.K., Wang, S., Smith, D., Carlin, A.F. and Rana, T.M. Revealing tissue-specific SARS-CoV-2 infection and host responses using human stem cell-derived lung and brain organoids. Representative of stem cells. 16437-445 (2021).
Lamers, MM et al. An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II cells. EMBO J. 40e105912 (2021).
Han, Y. et al. Identification of SARS-CoV-2 inhibitors using lung and colon organoids. Nature 589270-275 (2021).
Youk, J. et al. Three-dimensional human alveolar stem cell culture models reveal infectious response to SARS-CoV-2. Stem cell 27905-919.e910 (2020).
Jung, JH et al. SARS-CoV-2-specific T cell memory is maintained in convalescent COVID-19 patients for 10 months through the successful development of stem cell-like memory T cells. Nat. Common. 124043 (2021).
Lipsitch, M., Grad, YH, Sette, A. and Crotty, S. Cross-reactive memory T cells and herd immunity against SARS-CoV-2. Nat. Reverend Immunol. 20709-713 (2020).
Dan, JM et al. Immunological memory to SARS-CoV-2 assessed up to 8 months after infection. Science 371eabf4063 (2021).
Schaller, MA et al. Ex vivo SARS-CoV-2 infection of the human lung reveals heterogeneous host defense and therapeutic responses. JCI Overview 6e148003 (2021).
Lee-Ferris, RE et al. Prolonged culture of airway explants allows for the study of health, disease, and viral pathogenesis. Sci. Av. 11eadp0451 (2025).
Neal, JT et al. Organoid modeling of the tumor immune microenvironment. Cell 1751972-1988.e1916 (2018).
Ootani, A. et al. In vitro intestinal epithelial culture supported in a Wnt-dependent stem cell niche. Nat. Med. 15701-706 (2009).
Santos, AJM et al. A human autoimmune organoid model reveals the function of IL-7 in celiac disease. Nature 632401-410 (2024).
Mulay, A. et al. SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery. Cell Representative. 35109055 (2021).
Hou, YJ et al. Reverse genetics of SARS-CoV-2 reveals a variable infection gradient in the respiratory tract. Cell 182429-446.e414 (2020).
Beers, MF & Moodley, Y. When is a type 2 alveolar cell a type 2 alveolar cell? An enigma for pulmonary stem cell biology and regenerative medicine. Am. J. Breathe. Cell Mol. Biol. 5718-27 (2017).
Shenoy, AT et al. Antigen presentation by lung epithelial cells directs CD4. Nat. Common. 125834 (2021).
Wosen, JE, Mukhopadhyay, D., Macaubas, C. & Mellins, ED Epithelial MHC class II expression and its role in antigen presentation in the gastrointestinal and respiratory tract. In front. Immunol. 92144 (2018).
Hoffmann, M. et al. SARS-CoV-2 cell entry is dependent on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181271-280.e278 (2020).
Co, JY et al. Control of epithelial polarity: a human enteroid model for host-pathogen interactions. Cell Representative. 262509-2520.e2504 (2019).
Gn Health
