Emotion regulation ability does not have a shared neural signature

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  • Sheppes, G., Suri, G. & Gross, JJ Emotion regulation and psychopathology. Ann. Reverend Clin. Psychological. 11379-405 (2015).

    Article PubMed Google Scholar

  • Morawetz, C. et al. Multiple large-scale neural networks underlying emotion regulation. Neuroscience. Biobehavior. Round. 116382-395 (2020).

    Article PubMed Google Scholar

  • Morawetz, C. & Basten, U. Neural basis of individual differences in emotion regulation: a systematic review. Neuroscience. Biobehavior. Round. 162105727 (2024).

    Article PubMed Google Scholar

  • Sicorello, M. & Schmahl, C. Emotional dysregulation in borderline personality disorder: a fronto-limbic imbalance? Curr. Notice. Psychological. 37114-120 (2021).

    Article PubMed Google Scholar

  • Picó-Pérez, M., Radua, J., Steward, T., Menchón, J.M. and Soriano-Mas, C. Emotion regulation in mood and anxiety disorders: a meta-analysis of fMRI cognitive reappraisal studies. Program. Neuropsychopharmacol. Biol. Psychiatry 7996-104 (2017).

    Article PubMed Google Scholar

  • Kang, Y. Focused transcranial ultrasound for emotion regulation: a systematic review and quantitative summary of human studies. J. Affect. Mess. https://doi.org/10.1016/j.jad.2026.121621 (2026).

    Article PubMed Google Scholar

  • Tschentscher, N. et al. The clinical impact of real-time fMRI neurofeedback on emotion regulation: a systematic review. Brain science. 14700 (2024).

    Article PubMed PubMed Central Google Scholar

  • Goldental, N. et al. Effects of EFP amygdala neurofeedback on PTSD symptom clusters and emotional regulation processes. J. Clin. Med. 142421 (2025).

    Article CAS PubMed PubMed Central Google Scholar

  • Kievit, RA, Frankenhuis, WE, Waldorp, LJ & Borsboom, D. Simpson’s paradox in psychological science: a practical guide. In front. Psychological. https://doi.org/10.3389/fpsyg.2013.00513. (2013).

    Article PubMed PubMed Central Google Scholar

  • Kragel, PA et al. Generalizable representations of pain, cognitive control, and negative emotions in medial frontal cortex. Nat. Neuroscience. 21283-289 (2018).

    Article CAS PubMed PubMed Central Google Scholar

  • McDermott, TJ, Kirlic, N. & Aupperle, RL Roadmap for maximizing the clinical utility of emotional stress paradigms in human neuroimaging research. Neurobiol. Stress 8134-146 (2018).

    Article PubMed PubMed Central Google Scholar

  • Sicorello, M. et al. The functional neurobiology of dispositions toward negative emotions. Nat. Common. 175622 (2026).

    Article CAS PubMed PubMed Central Google Scholar

  • Marek, S. et al. Reproducible brain-wide association studies require thousands of individuals. Nature 603654-660 (2022).

    Article ADS CAS PubMed PubMed Central Google Scholar

  • Khodadadifar, T. et al. Searching for a convergent regional brain abnormality in cognitive emotion regulation: a transdiagnostic neuroimaging meta-analysis. Hmm. Brain map. 431309-1325 (2022).

    Article PubMed Google Scholar

  • Morawetz, C., Hemetsberger, FJ, Laird, AR & Kohn, N. Emotion regulation: from neural circuits to a transdiagnostic perspective. Neuroscience. Biobehavior. Round. 168105960 (2025).

    Article PubMed Google Scholar

  • Drabant, EM, McRae, K., Manuck, SB, Hariri, AR & Gross, JJ Individual differences in typical use of reappraisal predict amygdala and prefrontal responses. Biol. Psychiatry 65367-373 (2009).

    Article PubMed Google Scholar

  • McRae, K., Jacobs, SE, Ray, RD, John, OP & Gross, JJ Individual differences in reappraisal ability: Links to reappraisal frequency, well-being, and cognitive control. J. Res. Staff. 462-7 (2012).

    Google Scholar article

  • Silvers, JA & Guassi Moreira, JF Ability and tendency: a neuroscientific framework for the study of emotion regulation. Neuroscience. Lett. 69335-39 (2019).

    Article CAS PubMed Google Scholar

  • Kang, T. et al. High-intensity transcranial alternating current stimulation for emotion regulation and attentional biases in adolescents with non-suicidal self-injury: a randomized clinical trial. JAMA Network. Open 9e2617336 (2026).

    Article PubMed PubMed Central Google Scholar

  • Goldin, P. et al. Cognitive reappraisal self-efficacy mediates the effects of individual cognitive behavioral therapy for social anxiety disorder. J. Consult. Clin. Psychological. 801034-1040 (2012).

    Article PubMed PubMed Central Google Scholar

  • Brehl, A.-K., Schene, A., Kohn, N. & Fernández, G. Maladaptive emotion regulation strategies in a vulnerable population predict increased anxiety during the Covid-19 pandemic: a pseudo-prospective study. J. Affect. Mess. representative 4100113 (2021).

    Google Scholar

  • Ward, DPI et al. Individual differences in hemoglobin concentration influence fMRI bold functional connectivity and its correlation with cognition. NeuroImage 221117196 (2020).

    Article CAS PubMed PubMed Central Google Scholar

  • Bet, TD CanlabCore. GitHub https://github.com/canlab/CanlabCore (2024).

  • Wager, TD, Davidson, ML, Hughes, BL, Lindquist, MA & Ochsner, KN Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron 591037-1050 (2008).

    Article CAS PubMed PubMed Central Google Scholar

  • Thomas Yeo, BT et al. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J. Neurophysiol. 1061125-1165 (2011).

    Google Scholar article

  • Hedge, C., Powell, G. & Sumner, P. The reliability paradox: why robust cognitive tasks do not produce reliable individual differences. Behavior. Res. Methods 501166-1186 (2018).

    Article PubMed PubMed Central Google Scholar

  • Zhang, J.-X., Bo, K., Wager, TD & Gross, JJ The brain bases of emotion generation and regulation. Cogn. Trends Sci. 29879-891 (2025).

    Article PubMed Google Scholar

  • Mauss, IB & Robinson, MD Measures of emotion: a review. Cogn. Emot. 23209-237 (2009).

    Article PubMed PubMed Central Google Scholar

  • Taschereau-Dumouchel, V., Kawato, M. & Lau, H. Multivoxel model analysis reveals dissociations between subjective fear and its physiological correlates. Mol. Psychiatry https://doi.org/10.1038/s41380-019-0520-3 (2019).

    Article PubMed PubMed Central Google Scholar

  • Chang, LJ, Gianaros, PJ, Manuck, SB, Krishnan, A. & Wager, TD A sensitive and specific neural signature for image-induced negative affect. PLoS Biol. 131-28 (2015).

    CAS article Google Scholar

  • Zhou, F. et al. A distributed fMRI-based signature for the subjective experience of fear. Nat. common. 6643 (2021).

  • Cunningham, WA & Brosch, T. Motivational salience: tuning the amygdala from traits, needs, values, and goals. Curr. Real. Psychological. Sci. 2154-59 (2012).

    Google Scholar article

  • Paré, D. & Headley, DB The amygdala mediates the facilitative influence of emotions on memory through multiple interaction mechanisms. Neurobiol. Stress 24100529 (2023).

    Article PubMed PubMed Central Google Scholar

  • Marek, S. et al. Brain-wide patterns of associations reflect socioeconomics. Science 392eaee6213 (2026).

    Article CAS PubMed Google Scholar

  • Hu, Y.-T. et al. Repetitive transcranial magnetic stimulation of the motor cortex in major depressive disorder – a preliminary randomized controlled clinical trial. J. Affect. Mess. 344169-175 (2024).

    Article PubMed Google Scholar

  • Bramson, B., Toni, I. and Roelofs, K. Emotion regulation from an action control perspective. Neuroscience. Biobehavior. Round. 153105397 (2023).

    Article PubMed Google Scholar

  • Suri, G. Allocations and the mechanisms underlying revaluation. In Emotion Regulation Handbook 3rd ed., 104-111 (Guilford Press, 2024).

  • Herzog, S. et al. A neural signature for reappraisal as an emotion regulation strategy: Relationship to stress-related suicidal ideation and negative affect in major depression. Biol. Psychiatry Cogn. Neuroscience. Neuroimaging 1094-102 (2025).

    PubMed Google Scholar

  • Shafir, R., Thiruchselvam, R., Suri, G., Gross, JJ & Sheppes, G. Neural processing of emotional intensity predicts emotion regulation choice. Soc. Cogn. Affect. Neuroscience. 111863-1871 (2016).

    Article PubMed PubMed Central Google Scholar

  • Inzlicht, M., Werner, KM, Briskin, JL and Roberts, BW Integrating models of self-regulation. Ann. Round….

    • Gn Health

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