Fagarasan, S. Evolution, development, mechanism and function of IgA in the intestine. Curr. Notice. Immunol. 20170-177 (2008).
Pabst, O. & Slack, E. IgA and the gut microbiota: the importance of being specific. Mucosal immunol. 1312-21 (2020).
Huus, KE, Petersen, C. & Finlay, BB Diversity and dynamism of IgA-microbiota interactions. Nat. Reverend Immunol. 21514-525 https://doi.org/10.1038/s41577-021-00506-1 (2021).
Catanzaro, JR et al. IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM. Sci. representative 913574 (2019).
Yel, L. Selective IgA deficiency. J. Clin. Immunol. 3010–16 https://doi.org/10.1007/s10875-009-9357-x (2010).
Fadlallah, J. et al. Disruption of microbial ecology in human IgA deficiency. Sci. Trans. Med. 10eaan1217 (2018).
Conrey, PE et al. IgA deficiency destabilizes homeostasis with respect to intestinal microbes and increases systemic immune dysregulation. Sci. Immunol. 8eade2335 (2023).
Moll, JM et al. The disruption of the intestinal microbiota in cases of IgA deficiency is influenced by the status of IgA autoantibodies. Gastroenterology 1602423-2434 https://doi.org/10.1053/j.gastro.2021.02.053 (2021).
Shroff, KE, Meslin, K. and Cebra, JJ Commensal enteric bacteria elicit a self-limiting mucosal humoral immune response while permanently colonizing the gut. Infect. Immune. 633904-3913 (1995).
Singh, K., Chang, C. and Gershwin, ME IgA deficiency and autoimmunity. Autoimmune. Round. 13163-177 (2014).
Ludvigsson, J.F., Neovius, M., Ye, W. & Hammarström, L. IgA deficiency and cancer risk: a population-based matched cohort study. J. Clin. Immunol. 35182-188 (2015).
Langford, TD et al. Central importance of immunoglobulin A in host defense against Giardia spp. Infect. Immune. 7011-18 (2002).
Blutt, SE, Miller, AD, Salmon, SL, Metzger, DW & Conner, ME IgA is important for clearance and essential for protection against rotavirus infection. Mucosal immunol. 5712-719 (2012).
Moor, K. et al. High-avidity IgA protects the gut by shackling growing bacteria. Nature 544498-502 (2017).
Jorgensen, SF et al. Selective IgA deficiency in humans is associated with reduced intestinal microbial diversity. J. Allergy Clin. Immunol. 1431969-1971 (2019).
Gatti, RA & Good, RA Appearance of malignancies in immunodeficiency diseases: a review of the literature. Cancer 2889-98 (1971).
Filipovich, AH, Mathur, A., Kamat, D., Kersey, JH & Shapiro, RS Lymphoproliferative disorders and other tumors complicating immune deficiencies. Immunodeficiency 591-112 (1994).
Ludvigsson, JF, Neovius, M. & Hammarström, L. IgA deficiency and mortality: a population-based cohort study. J. Clin. Immunol. 331317-1324 (2013).
Cunningham-Rundles, C., Pudifin, DJ, Armstrong, D. & Good, RA Selective IgA deficiency and neoplasia. Vox sang. 3861-67 (1980).
Pulvirenti, F. et al. Gastric cancer is the leading cause of death in Italian adult patients with common variable immunodeficiency. In front. Immunol. 92546 (2018).
Shulzhenko, N. et al. Crosstalk between B cells, microbiota, and intestinal epithelium governs immunity versus metabolism in the gut. Nat. Med. 171585-1593 (2011).
Kawamoto, S. et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the intestine. Science 336485-489 (2012).
Kubinak, JL et al. MyD88 signaling in T cells directs IgA-mediated microbiota control to promote health. Cell host microbe 17153-163 (2015).
Suzuki, K. et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient intestine. Proc. Natl Acad. Sci. USA 1011981-1986 (2004).
Fagarasan, S. et al. Critical roles of activation-induced cytidine deaminase in intestinal flora homeostasis. Science 2981424-1427 (2002).
Gopalakrishna, KP et al. Maternal IgA protects against the development of necrotizing enterocolitis in premature infants. Nat. Med. 2511:10-11:15 a.m. (2019).
Kawamoto, S. et al. Foxp3+ T lymphocytes regulate the selection of immunoglobulins and facilitate the diversification of bacterial species responsible for immune homeostasis. Immunity 41152-165 (2014).
Nagashima, K. et al. Identification of subepithelial mesenchymal cells that induce IgA and diversify the intestinal microbiota. Nat. Immunol. 18675-682 (2017).
Peterson, DA et al. Characterize the interactions between a naturally primed immunoglobulin A and its conserved substance Bacteroides thetaiotaomicron Species-specific epitope in gnotobiotic mice. J. Biol. Chemical. 29012630-12649 https://doi.org/10.1074/jbc.m114.633800 (2015).
Nakajima, A. et al. IgA regulates the composition and metabolic function of the intestinal microbiota by promoting symbiosis between bacteria. J.Exp. Med. 2152019-2034 (2018).
Donaldson, GP et al. The intestinal microbiota uses immunoglobulin A for colonization of the mucous membranes. Science 360795-800 (2018).
Rollenske, T. et al. Intestinal secretory IgA parallelism shapes functional microbial fitness. Nature 598657-661 https://doi.org/10.1038/s41586-021-03973-7 (2021).
Harriman, GR et al. Targeted deletion of the IgA constant region in mice results in IgA deficiency with alterations in the expression of other Ig isotypes. J. Immunol. 1622521-2529 (1999).
Murthy, AK, Dubose, CN, Banas, JA, Coalson, JJ and Arulanandam, BP Contribution of the polymeric immunoglobulin receptor to the regulation of intestinal inflammation in dextran sulfate sodium-induced colitis. J. Gastroenterol. Hepatol. 211372-1380 (2006).
Mathias, A. & Corthésy, B. N-Glycans on the secretory component: mediators of the interaction between secretory IgA and Gram-positive commensals supporting intestinal homeostasis. Gut microbes 2287-293 (2011).
Kaetzel, CS The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunol. Round. 20683-99 (2005).
Ramanan, D. et al. An immunological mode of multigenerational transmission governs an intestinal Treg set point. Cell 1811276-1290 (2020).
van der Post, S., Birchenough, GMH & Held, JM NOX1-dependent redox signaling potentiates…
Gn Health
